mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation

Author:

Levy Oren123,Zhao Weian123,Mortensen Luke J.4,LeBlanc Sarah123,Tsang Kyle123,Fu Moyu123,Phillips Joseph A.4,Sagar Vinay123,Anandakumaran Priya123,Ngai Jessica123,Cui Cheryl H.123,Eimon Peter5,Angel Matthew5,Lin Charles P.4,Yanik Mehmet Fatih56,Karp Jeffrey M.123

Affiliation:

1. Division of Biomedical Engineering, Department of Medicine, Center for Regenerative Therapeutics, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA;

2. Harvard Stem Cell Institute, Cambridge, MA;

3. Harvard—Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, MA;

4. Wellman Center for Photomedicine and Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; and

5. Department of Biological Engineering and

6. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA

Abstract

Key Points mRNA transfection is an effective tool to simultaneously engineer MSCs for enhanced homing and improved secretome. MSCs can be systemically targeted to sites of inflammation to achieve therapeutically relevant concentrations of biological agents.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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