Phosphonodiamidate prodrugs of phosphoantigens (ProPAgens) exhibit potent Vγ9/Vδ2 T cell activation and eradication of cancer cells-Reference-Cited by-同舟云学术

Phosphonodiamidate prodrugs of phosphoantigens (ProPAgens) exhibit potent Vγ9/Vδ2 T cell activation and eradication of cancer cells

Published:2024 Issue:7 Volume:15 Page:2462-2473
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Xu Qin¹,Sharif Maria²³,James Edward¹,Dismorr Jack O.⁴,Tucker James H. R.⁴^ORCID,Willcox Benjamin E.²³^ORCID,Mehellou Youcef¹⁵^ORCID

Affiliation:

1. School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK

2. Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK

3. Cancer Immunology and Immunotherapy Centre, University of Birmingham, Birmingham B15 2TT, UK

4. School of Chemistry, University of Birmingham, Birmingham B15 2TT, UK

5. Medicines Discovery Institute, Cardiff University, Cardiff CF10 3AT, UK

Abstract

Phosphonodiamidate prodrugs of the monophosphonate derivatives of HMBPP, a natural phosphoantigen, exhibit potent activation of Vγ9Vδ2 T cells resulting in the lysis of bladder cancer cells in vitro.

Funder

Medical Research Council

Wellcome Trust

Rosetrees Trust

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00208C

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