Adaptive Immune Response of Vγ2Vδ2 + T Cells During Mycobacterial Infections-Reference-Cited by-同舟云学术

Adaptive Immune Response of Vγ2Vδ2 + T Cells During Mycobacterial Infections

Published:2002-03-22 Issue:5563 Volume:295 Page:2255-2258
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Shen Yun¹²,Zhou Dejiang¹²,Qiu Liyou¹²,Lai Xioamin¹²,Simon Meredith³,Shen Ling²,Kou Zhongchen¹²,Wang Qifan¹²,Jiang Liming¹²,Estep Jim⁴,Hunt Robert⁴,Clagett Michelle⁴,Sehgal Prabhat K.³,Li Yunyaun¹²,Zeng Xuejun¹²,Morita Craig T.⁵,Brenner Michael B.⁶,Letvin Norman L.²,Chen Zheng W.¹²

Affiliation:

1. Tuberculosis Research Unit,

2. Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

3. New England Regional Primate Research Center, Southboro, MA 01772, USA.

4. Battelle Medical Research and Evaluation Facility, Battelle Memorial Institute, Columbus, Ohio 43201, USA.

5. Division of Rheumatology, Department of Internal Medicine, and the Interdisciplinary Group on Immunology, University of Iowa, Iowa City, IA 52242, USA.

6. Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Abstract

To examine the role of T cell receptor (TCR) in γδ T cells in adaptive immunity, a macaque model was used to follow Vγ2Vδ2 + T cell responses to mycobacterial infections. These phosphoantigen-specific γδ T cells displayed major expansion during Mycobacterium bovis Bacille Calmette-Guérin (BCG) infection and a clear memory-type response after BCG reinfection. Primary and recall expansions of Vγ2Vδ2 + T cells were also seen during Mycobacterium tuberculosis infection of naı̈ve and BCG-vaccinated macaques, respectively. This capacity to rapidly expand coincided with a clearance of BCG bacteremia and immunity to fatal tuberculosis in BCG-vaccinated macaques. Thus, Vγ2Vδ2 + T cells may contribute to adaptive immunity to mycobacterial infections.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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