Target identification among known drugs by deep learning from heterogeneous networks

Author:

Zeng Xiangxiang1234,Zhu Siyi5674,Lu Weiqiang8910114,Liu Zehui121314154,Huang Jin121314154ORCID,Zhou Yadi1617181920,Fang Jiansong1617181920,Huang Yin1617181920,Guo Huimin2122234,Li Lang2425262720,Trapp Bruce D.2817181920,Nussinov Ruth2930313233ORCID,Eng Charis1617181920,Loscalzo Joseph3435363720,Cheng Feixiong1617181920ORCID

Affiliation:

1. College of Information Science and Engineering

2. Hunan University

3. Changsha

4. China

5. Department of Computer Science

6. Xiamen University

7. Xiamen

8. Shanghai Key Laboratory of Regulatory Biology

9. Institute of Biomedical Sciences and School of Life Sciences

10. East China Normal University

11. Shanghai 200241

12. Shanghai Key Laboratory of New Drug Design

13. School of Pharmacy

14. East China University of Science and Technology

15. Shanghai 200237

16. Genomic Medicine Institute

17. Lerner Research Institute

18. Cleveland Clinic

19. Cleveland

20. USA

21. Key Laboratory of Drug Quality Control and Pharmacovigilance

22. China Pharmaceutical University

23. Nanjing 210009

24. Department of Biomedical Informatics

25. College of Medicine

26. The Ohio State University

27. Columbus

28. Department of Neurosciences

29. Cancer and Inflammation Program

30. Leidos Biomedical Research, Inc.

31. Frederick National Laboratory for Cancer Research

32. National Cancer Institute at Frederick

33. Frederick

34. Department of Medicine

35. Brigham and Women's Hospital

36. Harvard Medical School

37. Boston

Abstract

Target identification and drug repurposing could benefit from network-based, rational deep learning prediction, and explore the relationship between drugs and targets in the heterogeneous drug–gene–disease network.

Funder

Foundation for the National Institutes of Health

National Institute of Neurological Disorders and Stroke

National Heart, Lung, and Blood Institute

American Heart Association

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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