Biotinylated Pt(iv) prodrugs with elevated lipophilicity and cytotoxicity

Author:

Spector Daniil12,Erofeev Alexander12ORCID,Gorelkin Peter12,Skvortsov Dmitry1ORCID,Trigub Alexander3,Markova Alina4,Nikitina Vita1,Ul'yanovskiy Nikolay5ORCID,Shtil’ Alexander6,Semkina Alevtina78,Vlasova Ksenia18,Zyk Nikolay1,Majouga Alexander9,Beloglazkina Elena1ORCID,Krasnovskaya Olga12ORCID

Affiliation:

1. Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1, 3, Moscow, 119991, Russia

2. National University of Science and Technology (MISIS), Leninskiy prospect 4, Moscow, 101000, Russia

3. National Research Center “Kurchatov Institute”, Akademika Kurchatova pl., 1, Moscow, 123182, Russia

4. Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Kosygin Street, 4, 119334, Moscow, Russia

5. Core Facility Center ‘Arktika’, Northern (Arctic) Federal University, Arkhangelsk, 163002, Russia

6. N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation, Kashirskoe highway 23, Moscow, 115478, Russia

7. Pirogov Russian National Research Medical University (RNRMU), Ostrovitianov str. 1, Moscow, 117997, Russia

8. Serbsky National Medical Research Center for Psychiatry and Narcology, Department of Basic and Applied Neuro-biology, Kropotkinskiy 23, Moscow, 119034, Russia

9. Mendeleev University of Chemical Technology of Russia, Miusskaya sq. 9, Moscow, 125047, Russia

Abstract

A design of Pt(iv) prodrugs with tumor cell targeting moieties leading to increased selectivity is of interest.

Funder

Ministry of Education and Science of the Russian Federation

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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