Skin-permeating components of Lonicera japonica flos: a comprehensive study from observations and model computations

Author:

Zhang Keda12345ORCID,Sun Wanyang67894,Fahr Alfred10111213ORCID,Zeng Xiaobin1234,Ge Lanlan1234,Chen Ming1415164ORCID,Yang Lingzhi171819204,Wu Shipin212224,Fei Jia232494,Zhou Boping1234

Affiliation:

1. Central Laboratory of Longhua Branch

2. Second Clinical Medical College (Shenzhen People's Hospital) of Jinan University

3. Shenzhen 518109

4. China

5. Integrated Chinese and Western Medicine Postdoctoral Research Station

6. Institute of Traditional Chinese Medicine & Natural Products

7. College of Pharmacy

8. Jinan University

9. Guangzhou 510632

10. Department of Pharmaceutical Technology

11. Friedrich-Schiller-Universität Jena

12. Jena 07743

13. Germany

14. State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology

15. College of Ocean and Earth Sciences, Xiamen University

16. Xiamen 361102

17. School of Pharmaceutical Sciences

18. Health Science Center

19. Shenzhen University

20. Shenzhen 518060

21. Department of Infectious Disease

22. Shenzhen 518020

23. Department of Biochemistry and Molecular Biology

24. Medical College of Jinan University

Abstract

Flavonoids and essential oils are well absorbed via the skin, while chlorogenic acids, iridoid glycosides and triterpenoids are poorly delivered.

Funder

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Reference28 articles.

1. C.-H. Hempen and T.Fischer , in A Materia Medica for Chinese Medicine: Plants, Minerals, and Animal Products , ed. C.-H. Hempen and T. Fischer , Churchill Livingstone , Edinburgh , 2009 , pp. 110–263

2. A target and nontarget strategy for identification or characterization of the chemical ingredients in Chinese herb preparation Shuang-Huang-Lian oral liquid by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry

3. Lonicera japonica Thunb.: Ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine

4. G. W. Lu and G. L.Flynn , in Modern Pharmaceutics , ed. A. T. Florence and J. Siepmann , Informa Healthcare , New York , 5 edn, 2009 , vol. 2, pp. 43–100

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