Concentration of Antioxidant Compounds from Calendula officinalis through Sustainable Supercritical Technologies, and Computational Study of Their Permeability in Skin for Cosmetic Use
-
Published:2021-12-30
Issue:1
Volume:11
Page:96
-
ISSN:2076-3921
-
Container-title:Antioxidants
-
language:en
-
Short-container-title:Antioxidants
Author:
Mur Raquel,
Langa Elisa,
Pino-Otín M. Rosa,
Urieta José S.ORCID,
Mainar Ana M.ORCID
Abstract
The growing interest in the cosmetic industry in using compounds of natural and sustainable origin that are safe for humans is encouraging the development of processes that can satisfy these needs. Chlorogenic acid (CHA), caffeic acid (CAF) and ferulic acid (FA) are three compounds widely used within the cosmetic industry due to their functionalities as antioxidants, collagen modifiers or even as radiation protectors. In this work, two advanced separation techniques with supercritical CO2 are used to obtain these three compounds from Calendula officinalis, and these are then evaluated using a computational skin permeability model. This model is encompassed by the COSMO-RS model, the calculations of which make it possible to study the behaviour of the compounds in the epidermis. The results show that both CAF and FA are retained in the stratum corneum, while CHA manages to penetrate to the stratum spinosum. These compounds were concentrated by antisolvent fractionation with super-critical CO2 using a Response Surface Methodology to study the effect of pressure and CO2 flow rate. CHA, CAF and FA were completely retained in the precipitation vessel, with concentrations between 40% and 70% greater than in the original extract. The conditions predicted that the optimal overall yield and enrichment achieved would be 153 bar and 42 g/min.
Funder
European Regional Development Fund
Gobierno de Aragón: Departamento de Ciencia, Universidad y Sociedad del Conocimiento
Subject
Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology
Reference90 articles.
1. A review on phytochemistry and ethnopharmacological aspects of genus Calendula
2. Herbal Medicines;Barnes,2007
3. ESCOP Monographs, The Scientific Foundation for Herbal Medicinal Products. Online Series. Calendulae Flos (Calendula Flower),2019
4. European Medicines Agency Overview of Comments Recieved on Community Herbal Monograph on Calendula officinalis L., Floshttps://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-calendula-officinalis-l-flos-revision-1_en.pdf
5. WHO Monographs on Selected Medicinal Plants,2002
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献