A highly efficient metal-free approach to meta- and multiple-substituted phenols via a simple oxidation of cyclohexenones

Author:

Liang Yu-Feng12345,Song Song12345,Ai Lingsheng12345,Li Xinwei12345,Jiao Ning12345

Affiliation:

1. State Key Laboratory of Natural and Biomimetic Drugs

2. School of Pharmaceutical Sciences

3. Peking University

4. Beijing 100191

5. China

Abstract

The simple and readily available I2 catalyst, and a cheap and common DMSO oxidant could be employed for the transformation of cyclohexenones to meta- and multiple-substituted phenols with significant tolerance to various functional substituents.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Reference97 articles.

1. J. H. P. Tyman , Synthetic and Natural Phenols, Elsevier, New York, 1996

2. Z. Rappoport , The Chemistry of Phenols, Wiley-VCH, Weinheim, 2003

3. P. M. Dewick , Medicinal Natural Products: A Biosynthetic Approach, Wiley-VCH, Weinheim, 2011

4. The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

5. C. A. Fyfe , The Chemistry of the Hydroxyl Group, Wiley-Interscience, New York, 1971

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