Discovery and bioinspired total syntheses of unprecedented sesquiterpenoid dimers unveiled bifurcating [4 + 2] cycloaddition and target differentiation of enantiomers

Author:

He Tao-Bin1,Yan Bing-Chao1ORCID,Zhou Yuan-Fei2,Sang Yue-Qian3,Li Xiao-Nian1,Sun Han-Dong1ORCID,Wang Chu2ORCID,Xue Xiao-Song3ORCID,Puno Pema-Tenzin1ORCID

Affiliation:

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China

2. Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

3. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai200032, China

Abstract

The [4 + 2] cycloaddition has led to diverse polycyclic chiral architectures, serving as novel sources for organic synthesis and biological exploration.

Funder

National Natural Science Foundation of China

National Science Fund for Distinguished Young Scholars

Natural Science Foundation of Yunnan Province

Youth Innovation Promotion Association of the Chinese Academy of Sciences

China Postdoctoral Science Foundation

Yunnan Provincial Science and Technology Department

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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