Synthesis and evaluation of new benzimidazole-based COX inhibitors: a naproxen-like interaction detected by STD-NMR-Reference-Cited by-同舟云学术

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Synthesis and evaluation of new benzimidazole-based COX inhibitors: a naproxen-like interaction detected by STD-NMR

Published:2015 Issue:61 Volume:5 Page:49098-49109
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Carvalho Luísa C. R.¹²³⁴⁵,Ribeiro Daniela⁶⁷⁸⁹¹⁰,Seixas Raquel S. G. R.¹¹¹²¹³¹⁴,Silva Artur M. S.¹¹¹²¹³¹⁴,Nave Mariana¹²³⁴⁵,Martins Ana C.¹²³⁴⁵,Erhardt Stefan¹⁵¹⁶¹⁷¹⁸¹⁹,Fernandes Eduarda⁶⁷⁸⁹¹⁰,Cabrita Eurico J.⁶²³⁴²⁰,Marques M. Manuel B.¹²³⁴⁵

Affiliation:

1. LAQV@REQUIMTE

2. Departamento de Química

3. Faculdade de Ciências e Tecnologia

4. Universidade Nova de Lisboa

5. Campus de Caparica

6. UCIBIO@REQUIMTE

7. Departamento de Ciências Químicas

8. Laboratório de Química Aplicada

9. Faculdade de Farmácia

10. Universidade do Porto

11. QOPNA & Departamento de Química

12. Universidade de Aveiro

13. 3810-193 Aveiro

14. Portugal

15. School of Life

16. Sport and Social Sciences

17. Edinburgh Napier University

18. Edinburgh EH11 4BN

19. UK

20. 2829-516 Caparica

Abstract

Non-steroidal anti-inflammatory drugs exert their pharmacological activity through inhibition of cyclooxygenase 1 and 2 (COX-1 and COX-2).

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA04984A

Reference59 articles.

1. Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

2. Aspirin Selectively Inhibits Prostaglandin Production in Human Platelets

3. Indomethacin and Aspirin abolish Prostaglandin Release from the Spleen

4. Ibuprofen: from invention to an OTC therapeutic mainstay

5. Indomethacin: A New Non-steroid Anti-inflammatory Agent

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