A microfluidic immunosensor for automatic detection of carcinoembryonic antigen based on immunomagnetic separation and droplet arrays

Author:

Hu Haoran123ORCID,Cai Gaozhe2,Gao Zehang24ORCID,Liang Cheng5,Yang Fengna13,Dou Xiaohui13,Jia Chunping2,Zhao Jianlong2,Feng Shilun2,Li Bei13

Affiliation:

1. School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China

2. State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China

3. State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, 130033, PR China

4. Department of Clinical Laboratory, Third Affiliated Hospital of Guangzhou Medical University, Guangdong 510150, China

5. State Key Laboratory of Marine Resources Utilization in South China Sea and Center for Eco-Environment Restoration of Hainan Province, Hainan University, Haikou 570228, China

Abstract

Using immunomagnetic separation technology to enrich the target in the sample, combined with solid-phase surface modification technology to complete the quantitative detection of the sample concentration, enabling a more simplified detection process.

Funder

Chinese Academy of Sciences

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Reference35 articles.

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4. Electrochemical immunoassay based on polythionine as the signal source for the sensitive detection of carcinoma embryonic antigen

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