Biosensor-Based Nanodiagnosis of Carcinoembryonic Antigen (CEA): an Approach to Classification and Precise Detection of Cancer Biomarker
-
Published:2023-12-06
Issue:
Volume:
Page:
-
ISSN:2191-1630
-
Container-title:BioNanoScience
-
language:en
-
Short-container-title:BioNanoSci.
Author:
Hariri Maryam,Alivirdiloo Vahid,Ardabili Nastaran Safavi,Gholami Sarah,Masoumi Sajjad,Mehraban Mohammad Reza,Alem Mahsa,Hosseini Reza Shah,Mobed Ahmad,Ghazi Farhood,Alipourfard Iraj
Abstract
Abstract
The precise detection of cancer biomarkers is a principal aspect of effective diagnosis, monitoring, and therapeutics. Carcinoembryonic antigen (CEA) is a protein normally found in very small amounts in the blood of adults. CEA blood levels can be elevated in benign diseases and certain types of cancer. The CEA test is most commonly used to identify a significantly frequent cancer, colorectal cancer. It has decisive clinical value in monitoring, differential diagnosis, disease, and assessment of therapeutic effects. Therefore, it is important to develop a sensitive and simple CEA detection method to diagnose cancer and improve patient survival accurately. Biosensing has great advantages for early disease detection due to its rapid response, high sensitivity, and convenient operating characteristics. Based on several studies, biosensors seem to be new and promising paths in the future of medical oncology. The main purpose of this study is to introduce and discuss the recent nanodiagnostic biosensors developed since 2018. Therefore, the readers of this study will be introduced to the latest biosensors, the various nanomaterials used in them, and their analytical characteristics.
Graphical abstract
Publisher
Springer Science and Business Media LLC
Subject
Biomedical Engineering,Bioengineering
Reference119 articles.
1. Xi, Y., & Xu, P. (2021). Global colorectal cancer burden in 2020 and projections to 2040. Translational Oncology, 14(10), 101174. 2. Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., et al. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a Cancer Journal For Clinicians, 71(3), 209–249. 3. Hall, C., Clarke, L., Pal, A., Buchwald, P., Eglinton, T., Wakeman, C., et al. (2019). A review of the role of carcinoembryonic antigen in clinical practice. Annals of Coloproctology, 35(6), 294–305. 4. Schaap, D., Valk, K., Deken, M., Meijer, R., Burggraaf, J., Vahrmeijer, A., et al. (2020). Carcinoembryonic antigen-specific, fluorescent image-guided cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for metastatic colorectal cancer, 107(4), 334–337. 5. Mazloum-Ardakani, M., Tavakolian-Ardakani, Z., Sahraei, N., & Moshtaghioun, S. M. J. B. (2019). Bioelectronics. Fabrication of an ultrasensitive and selective electrochemical aptasensor to detect carcinoembryonic antigen by using a new nanocomposite, 129, 1–6.
|
|