Implications for blood-brain-barrier permeability, in vitro oxidative stress and neurotoxicity potential induced by mesoporous silica nanoparticles: effects of surface modification-Reference-Cited by-同舟云学术

Implications for blood-brain-barrier permeability, in vitro oxidative stress and neurotoxicity potential induced by mesoporous silica nanoparticles: effects of surface modification

Published:2016 Issue:4 Volume:6 Page:2800-2809
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhou Ming¹²³⁴⁵,Xie Linlin¹²³⁴⁵,Fang Chen-Jie¹²³⁴⁵,Yang Hua⁶⁵⁷⁸,Wang Yan-Jie⁹¹⁰¹¹¹²¹³,Zhen Xiao-Yu⁹¹⁰¹¹¹²¹³,Yan Chun-Hua⁹¹⁰¹¹¹²¹³,Wang Yuji¹²³⁴⁵,Zhao Ming¹²³⁴⁵,Peng Shiqi¹²³⁴⁵

Affiliation:

1. Beijing Area Major Laboratory of Peptide and Small Molecular Drugs

2. Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China

3. Beijing Laboratory of Biomedical Materials

4. College of Pharmaceutical Sciences

5. Capital Medical University

6. Medical Experimental & Test Centre

7. Beijing 100069

8. China

9. Beijing National Laboratory for Molecular Sciences

10. State Key Laboratory of Rare Earth Materials Chemistry and Applications

11. PKU-HKU Joint Laboratory on Rare Earth Materials and Bioinorganic Chemistry

12. Peking University

13. Beijing 100871

Abstract

MSNs are shown to have the potential to overcome the BBB and cause neuronal damage. However, the neurotoxicity potential could be mediated with surface modification.

Funder

Natural Science Foundation of Beijing Municipality

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA17517H

Reference90 articles.

1. Solid lipid nanoparticles for targeted brain drug delivery☆

2. Molecular Trojan horses for blood–brain barrier drug delivery