Lycopene inhibits hepatic stellate cell activation and modulates cellular lipid storage and signaling

Author:

Elias Monique de Barros123,Oliveira Felipe Leite453,Guma Fatima Costa Rodrigues673ORCID,Martucci Renata Brum453ORCID,Borojevic Radovan893ORCID,Teodoro Anderson Junger123ORCID

Affiliation:

1. Laboratory of Functional Foods

2. Universidade Federal do Estado do Rio de Janeiro

3. Brazil

4. Universidade Federal do Rio de Janeiro

5. Instituto de Ciências Biomédicas

6. Universidade Federal do Rio Grande do Sul

7. Biochemistry Department

8. Faculdade Arthur Sa Earp Neto Faculdade de Medicina de Petropolis

9. RJ

Abstract

Hepatic stellate cells are liver-specific perivascular cells, identified as the major source of collagen in liver fibrosis, following their activation and conversion to myofibroblast-like cells.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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