New Pd–Fe ferrocenyl antiparasitic compounds with bioactive 8-hydroxyquinoline ligands: a comparative study with their Pt

New Pd–Fe ferrocenyl antiparasitic compounds with bioactive 8-hydroxyquinoline ligands: a comparative study with their Pt–Fe analogues

Published:2021 Issue:5 Volume:50 Page:1651-1665
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Rivas Feriannys¹²³⁴⁵^ORCID,Medeiros Andrea⁶⁷⁸⁹¹⁰^ORCID,Quiroga Cristina⁶⁷⁸⁹^ORCID,Benítez Diego⁶⁷⁸⁹^ORCID,Comini Marcelo⁶⁷⁸⁹^ORCID,Rodríguez-Arce Esteban¹²³⁴⁵^ORCID,Machado Ignacio¹¹³⁴⁵⁹^ORCID,Cerecetto Hugo¹²¹³¹⁴⁴⁸^ORCID,Gambino Dinorah¹²³⁴⁵^ORCID

Affiliation:

1. Área Química Inorgánica

2. Programa de Posgrados

3. Facultad de Química

4. Universidad de la República

5. 11800 Montevideo

6. Group Redox Biology of Trypanosomes

7. Institut Pasteur de Montevideo

8. Montevideo

9. Uruguay

10. Departamento de Bioquímica

11. Área Química Analítica

12. Área de Radiofarmacia

13. CIN and Grupo de Química Orgánica Medicinal

14. IQB-Facultad de Ciencias

Abstract

Compounds displayed activity against T. brucei. A search of QSAR based on 18 Pt(ii)/Pd(ii) complexes was performed. A study in infected mice of the hit compound showed lack of acute toxicity and anti-proliferative effects that extend animal survival.

Funder

Agencia Nacional de Investigación e Innovación

Universidad de la República Uruguay

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/DT/D0DT03963B

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