Synthesis and molecular modeling studies of indole-based antitumor agents-Reference-Cited by-同舟云学术

Synthesis and molecular modeling studies of indole-based antitumor agents

Published:2016 Issue:51 Volume:6 Page:45434-45451
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

George Riham F.¹²³⁴⁵,Panda Siva S.⁶⁷⁸⁹,Shalaby El-Sayed M.¹⁰¹¹¹²¹³⁵,Srour Aladdin M.¹⁴¹²¹³⁵,Farag I. S. Ahmed¹⁰¹¹¹²¹³⁵,Girgis Adel S.¹⁵¹²¹³⁵

Affiliation:

1. Pharmaceutical Chemistry Department

2. Faculty of Pharmacy

3. Cairo University

4. Cairo

5. Egypt

6. Department of Chemistry & Physics

7. Augusta University

8. Augusta

9. USA

10. X-Ray Crystallography Lab

11. Physics Division

12. National Research Centre

13. Giza 12622

14. Therapeutical Chemistry Department

15. Pesticide Chemistry Department

Abstract

Potent antitumor active (HeLa, cervical carcinoma cell line) indole-based compounds were synthesized via azomethine ylide 1,3-dipolar cycloaddition with 3,5-arylidene-4-piperidones.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA07061B

Reference59 articles.

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3. Synthesis and antiviral properties of novel indole-based thiosemicarbazides and 4-thiazolidinones

4. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

5. Discovery of 5-[5-Fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic Acid (2-Diethylaminoethyl)amide, a Novel Tyrosine Kinase Inhibitor Targeting Vascular Endothelial and Platelet-Derived Growth Factor Receptor Tyrosine Kinase

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