Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial-Reference-Cited by-同舟云学术

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Published:2024-01-31 Issue:1 Volume:15 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

,Sandercock Peter,Darbyshire Janet,DeMets David,Fowler Robert,Lalloo David,Munavvar Mohammed,Warris Adilia,Wittes Janet,Cradduck-Bamford A.,Barton J.,Basoglu A.,Brown R.,Brudlo W.,Denis E.,Fletcher L.,Howard S.,Taylor K.,Cui G.,Goodenough B.,King A.,Lay M.,Murray D.,Stevens W.,Wallendszus K.,Wels R.,Crichton C.,Davies J.,Goldacre R.,Harper C.,Knight F.,Nunn M.,Salih H.,Welch J.,Zayed M.,Wiles J.,Bagley G.,Cameron S.,Chamberlain S.,Farrell B.,Freeman H.,Kennedy A.,Whitehouse A.,Wilkinson S.,Wood C.,Reith C.,Davies K.,Halls H.,Holland L.,Truell R.,Wilson K.,Howie L.,Lunn M.,Rodgers P.,Bowman L.,Chen F.,Clarke R.,Goonasekara M.,Herrington W.,Judge P.,Ng S.,Preiss D.,Sammons E.,Zhu D.,Barnard A.,Beety J.,Birch C.,Brend M.,Chambers E.,Chappell L.,Crawshaw S.,Drake C.,Duckles-Leech H.,Graham J.,Harman T.,Harper H.,Lock S.,Lomme K.,McMillan N.,Nickson I.,Ohia U.,OKell E.,Poustie V.,Sam S.,Sharratt P.,Sheffield J.,Slade H.,Van’t Hoff W.,Walker S.,Williamson J.,De Soyza A.,Dimitri P.,Faust S. 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Natalie,Campbell Mark,Pessoa-Amorim Guilherme,Mafham Marion,Emberson Jonathan R.^ORCID,Stewart Richard,Prudon Benjamin,Uriel Alison,Green Christopher A.^ORCID,Dhasmana Devesh J.,Malein Flora^ORCID,Majumdar Jaydip,Collini Paul^ORCID,Shurmer Jack,Yates Bryan,Baillie J. Kenneth^ORCID,Buch Maya H.^ORCID,Day Jeremy^ORCID,Faust Saul N.^ORCID,Jaki Thomas^ORCID,Jeffery Katie^ORCID,Juszczak Edmund^ORCID,Knight Marian,Lim Wei Shen,Montgomery Alan,Mumford Andrew,Rowan Kathryn^ORCID,Thwaites Guy^ORCID,Haynes Richard,Landray Martin J.^ORCID, , , , ,

Abstract

AbstractDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome.

Funder

DH | National Institute for Health Research

RCUK | Medical Research Council

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary

Link

https://www.nature.com/articles/s41467-023-43644-x.pdf

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