Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19-Reference-Cited by-同舟云学术

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

Published:2021-03-04 Issue:57 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Thwaites Ryan S¹^ORCID,Sanchez Sevilla Uruchurtu Ashley¹^ORCID,Siggins Matthew K¹^ORCID,Liew Felicity¹^ORCID,Russell Clark D²^ORCID,Moore Shona C³^ORCID,Fairfield Cameron⁴^ORCID,Carter Edwin⁵^ORCID,Abrams Simon³,Short Charlotte-Eve⁶^ORCID,Thaventhiran Thilipan⁶,Bergstrom Emma⁶,Gardener Zoe⁶,Ascough Stephanie⁶,Chiu Christopher⁶^ORCID,Docherty Annemarie B⁴⁷^ORCID,Hunt David⁸^ORCID,Crow Yanick J⁵,Solomon Tom³,Taylor Graham P⁶^ORCID,Turtle Lance³⁹^ORCID,Harrison Ewen M⁴^ORCID,Dunning Jake¹⁰^ORCID,Semple Malcolm G¹¹¹²^ORCID,Baillie J Kenneth⁷¹³^ORCID,Openshaw Peter JM¹^ORCID,>Baillie J Kenneth,Semple Malcolm G,Openshaw Peter JM,Alex Beatrice,Bach Benjamin,Barclay Wendy S,Bogaert Debby,Chand Meera,Cooke Graham S,Docherty Annemarie B,Dunning Jake,da Silva Filipe Ana,Fletcher Tom,Green Christopher A,Gupta Rishi K,Harrison Ewen M,Hiscox Julian A,Ho Antonia Ying Wai,Horby Peter W,Ijaz Samreen,Khoo Saye,Klenerman Paul,Law Andrew,Lim Wei Shen,Mentzer Alexander J,Merson Laura,Meynert Alison M,Noursadeghi Mahdad,Moore Shona C,Palmarini Massimo,Palmieri Carlo,Paxton William A,Pollakis Georgios,Price Nicholas,Rambaut Andrew,Robertson David L,Russell Clark D,Sancho-Shimizu Vanessa,Scott Janet T,de Silva Thushan,Sigfrid Louise,Solomon Tom,Sriskandan Shiranee,Stuart David,Summers Charlotte,Tedder Richard S,Thomson Emma C,AA Roger Thompson,Thwaites Ryan S,Turtle Lance,Zambon Maria,Hardwick Hayley,Donohue Chloe,Lyons Ruth,Griffiths Fiona,Oosthuyzen Wilna,Norman Lisa,Pius Riinu,Drake Tom M,Fairfield Cameron J,Knight Stephen,Mclean Kenneth A,Murphy Derek,Shaw Catherine A,Dalton Jo,Girvan Michelle,Saviciute Egle,Roberts Stephanie,Harrison Janet,Marsh Laura,Connor Marie,Halpin Sophie,Jackson Clare,Gamble Carrol,Leeming Gary,Law Andrew,Wham Murray,Clohisey Sara,Hendry Ross,Scott-Brown James,Greenhalf William,Shaw Victoria,McDonald Sarah,Keating Seán,Ahmed Katie A.,Armstrong Jane A,Ashworth Milton,Asiimwe Innocent G,Bakshi Siddharth,Barlow Samantha L,Booth Laura,Brennan Benjamin,Bullock Katie,Carlucci Nicola,Cass Emily,Catterall Benjamin WA,Clark Jordan J,Clarke Emily A,Cole Sarah,Cooper Louise,Cox Helen,Davis Christopher,Dincarslan Oslem,Carracedo Alejandra Doce,Dunn Chris,Dyer Philip,Elliott Angela,Evans Anthony,Finch Lorna,Fisher Lewis WS,Flaherty Lisa,Foster Terry,Garcia-Dorival Isabel,Greenhalf Willliam,Gunning Philip,Hartley Catherine,Holmes Anthony,Jensen Rebecca L,Jones Christopher B,Jones Trevor R,Khandaker Shadia,King Katharine,Kiy Robyn T.,Koukorava Chrysa,Lake Annette,Lant Suzannah,Latawiec Diane,Lavelle-Langham L,Lefteri Daniella,Lett Lauren,Livoti Lucia A,MacLean Alan,Massey Hannah,Maziere Nicole,Mancini Maria,McCafferty Sarah,McDonald Sarah,McEvoy Laurence,McLauchlan John,Metelmann Soeren,Miah Nahida S,Middleton Joanna,Mitchell Joyce,Moore Shona C,Morrice Kirstie,Murphy Ellen G,Murphy Lee,Penrice-Randal Rebekah,Pilgrim Jack,Prince Tessa,Reynolds Will,Ridley P. Matthew,Sales Debby,Shaw Victoria E,Shears Rebecca K,Small Benjamin,Subramaniam Krishanthi S,Szemiel Agnieska,Taggart Aislynn,Tanianis-Hughes Jolanta,Thomas Jordan,Trochu Erwan,van Tonder Libby,Wilcock Eve,Wrobel Nicola,Zhang J. Eunice,Adeniji Kayode,Agranoff Daniel,Agwuh Ken,Ail Dhiraj,Aldera Erin L,Alegria Ana,Angus Brian,Ashish Abdul,Atkinson Dougal,Bari Shahedal,Barlow Gavin,Barnass Stella,Barrett Nicholas,Bassford Christopher,Basude Sneha,Baxter David,Beadsworth Michael,Bernatoniene Jolanta,Berridge John,Best Nicola,Bothma Pieter,Brealey David,Brittain-Long Robin,Bulteel Naomi,Burden Tom,Burtenshaw Andrew,Caruth Vikki,Chadwick David,Chambler Duncan,Chee Nigel,Child Jenny,Chukkambotla Srikanth,Clark Tom,Cole Sarah,Collini Paul,Cosgrove Catherine,Cupitt Jason,Cutino-Moguel Maria-Teresa,Dark Paul,Dawson Chris,Dervisevic Samir,Donnison Phil,Douthwaite Sam,DuRand Ingrid,Dushianthan Ahilanadan,Dyer Tristan,Evans Cariad,Eziefula Chi,Fegan Chrisopher,Finn Adam,Fullerton Duncan,Garg Sanjeev,Garg Sanjeev,Garg Atul,Gkrania-Klotsas Effrossyni,Godden Jo,Goldsmith Arthur,Graham Clive,Hardy Elaine,Hartshorn Stuart,Harvey Daniel,Havalda Peter,Hawcutt Daniel B,Hobrok Maria,Hodgson Luke,Holme Anita,Hormis Anil,Jacobs Michael,Jain Susan,Jennings Paul,Kaliappan Agilan,Kasipandian Vidya,Kegg Stephen,Kelsey Michael,Kendall Jason,Kerrison Caroline,Kerslake Ian,Koch Oliver,Koduri Gouri,Koshy George,Laha Shondipon,Laird Steven,Larkin Susan,Leiner Tamas,Lillie Patrick,Limb James,Linnett Vanessa,Little Jeff,Lyttle Mark,MacMahon Michael,MacNaughton Emily,Mankregod Ravish,Masson Huw,Matovu Elijah,McCullough Katherine,McEwen Ruth,Meda Manjula,Mills Gary,Minton Jane,Mirfenderesky Mariyam,Mohandas Kavya,Mok Quen,Moon James,Moore Elinoor,Morgan Patrick,Morris Craig,Mortimore Katherine,Moses Samuel,Mpenge Mbiye,Mulla Rohinton,Murphy Michael,Nagel Megan,Nagarajan Thapas,Nelson Mark,O’Shea Matthew K,Otahal Igor,Ostermann Marlies,Pais Mark,Papineni Padmasayee,Panchatsharam Selva,Papakonstantinou Danai,Paraiso Hassan,Patel Brij,Pattinson Natalie,Pepperell Justin,Peters Mark,Phull Mandeep,Pintus Stefania,Pooni Jagtur Singh,Post Frank,Price David,Prout Rachel,Rae Nikolas,Reschreiter Henrik,Reynolds Tim,Richardson Neil,Roberts Mark,Roberts Devender,Rose Alistair,Rousseau Guy,Ryan Brendan,Saluja Taranprit,Shah Aarti,Shanmuga Prad,Sharma Anil,Shawcross Anna,Sizer Jeremy,Shankar-Hari Manu,Smith Richard,Snelson Catherine,Spittle Nick,Staines Nikki,Stambach Tom,Stewart Richard,Subudhi Pradeep,Szakmany Tamas,Tatham Kate,Thomas Jo,Thompson Chris,Thompson Robert,Tridente Ascanio,Tupper-Carey Darell,Twagira Mary,Ustianowski Andrew,Vallotton Nick,Vincent-Smith Lisa,Visuvanathan Shico,Vuylsteke Alan,Waddy Sam,Wake Rachel,Walden Andrew,Welters Ingeborg,Whitehouse Tony,Whittaker Paul,Whittington Ashley,Wijesinghe Meme,Williams Martin,Wilson Lawrence,Wilson Sarah,Winchester Stephen,Wiselka Martin,Wolverson Adam,Wooton Daniel G,Workman Andrew,Yates Bryan,Young Peter,

Affiliation:

1. National Heart and Lung Institute, Imperial College London, U.K.

2. University of Edinburgh Centre for Inflammation Research, Edinburgh, U.K.

3. Dept of Clinical Infection, Microbiology and Immunology, University of Liverpool, U.K.

4. Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, U.K.

5. Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, U.K.

6. Department of Infectious Disease, Faculty of Medicine, Imperial College London, U.K.

7. Intensive Care Unit, Royal Infirmary Edinburgh, Edinburgh, U.K.

8. Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, U.K.

9. Tropical and infectious disease unit, Liverpool University Hospitals NHS Foundation Trust (member of Liverpool Health Partners), U.K.

10. National Infection Service, Public Health England, London, UK

11. NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, U.K.

12. Respiratory Medicine, Alder Hey Children’s Hospital, Liverpool, U.K.

13. Roslin Institute, University of Edinburgh, Edinburgh, U.K.

Abstract

GM-CSF is elevated early, scaled with severity, and is central to the inflammatory response in COVID-19, but not severe influenza.

Funder

Bill and Melinda Gates Foundation

Wellcome

National Institute for Health Research

Medical Research Council

Public Health England

Liverpool Experimental Cancer Medicine Centre

UK Coronavirus Immunology Consortium