A new hyperpolarized 13C ketone body probe reveals an increase in acetoacetate utilization in the diabetic rat heart-Reference-Cited by-同舟云学术

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A new hyperpolarized 13C ketone body probe reveals an increase in acetoacetate utilization in the diabetic rat heart

Published:2019-04-02 Issue:1 Volume:9 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Abdurrachim Desiree,Woo Chern Chiuh,Teo Xing Qi,Chan Wei Xin,Radda George K.,Lee Philip Teck Hock

Funder

Asian Network for Translational Research and Cardiovascular Trial (ATTRACT), A*STAR Biomedical Research Council

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-019-39378-w.pdf

Reference50 articles.

1. Lopaschuk, G. D., Ussher, J. R., Folmes, C. D. L., Jaswal, J. S. & Stanley, W. C. Myocardial fatty acid metabolism in health and disease. Physiol. Rev. 90, 207–58 (2010).

2. Lopaschuk, G. D. & Ussher, J. R. Evolving concepts of myocardial energy metabolism: more than just fats and carbohydrates. Circ. Res. 119, 1173–1176 (2016).

3. Aubert, G. et al. The failing heart relies on ketone bodies as a fuel. Circulation 133, 698–705 (2016).

4. Bedi, K. C. et al. Evidence for intramyocardial disruption of lipid metabolism and increased myocardial ketone utilization in advanced human heart failure. Circulation 133, 706–716 (2016).

5. Cotter, D. G., Schugar, R. C., Wentz, A. E., Andre d’Avignon, D. & Crawford, P. A. Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation. AJP Endocrinol. Metab. 304, E363–E374 (2013).

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