Receptor tyrosine kinase Axl is required for resistance of leukemic cells to FLT3-targeted therapy in acute myeloid leukemia

Author:

Park I-K,Mundy-Bosse B,Whitman S P,Zhang X,Warner S L,Bearss D J,Blum W,Marcucci G,Caligiuri M A

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Reference43 articles.

1. Brown P, Small D . FLT3 inhibitors: a paradigm for the development of targeted therapeutics for paediatric cancer. Eur J Cancer 2004; 40: 707–721, discussion; 722–724.

2. Knapper S . FLT3 inhibition in acute myeloid leukaemia. Br J Haematol 2007; 138: 687–699.

3. Stirewalt DL, Radich JP . The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer 2003; 3: 650–665.

4. Gilliland DG, Griffin JD . The roles of FLT3 in hematopoiesis and leukemia. Blood 2002; 100: 1532–1542.

5. Whitman SP, Archer KJ, Feng L, Baldus C, Becknell B, Carlson BD et al. Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study. Cancer Res 2001; 61: 7233–7239.

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