The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study
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Published:2021-08-10
Issue:1
Volume:11
Page:
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ISSN:2158-3188
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Container-title:Translational Psychiatry
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language:en
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Short-container-title:Transl Psychiatry
Author:
Quattrone DiegoORCID, Reininghaus Ulrich, Richards Alex L.ORCID, Tripoli Giada, Ferraro Laura, Quattrone Andrea, Marino PaoloORCID, Rodriguez VictoriaORCID, Spinazzola Edoardo, Gayer-Anderson Charlotte, Jongsma Hannah E., Jones Peter B.ORCID, La Cascia Caterina, La Barbera Daniele, Tarricone Ilaria, Bonora Elena, Tosato SarahORCID, Lasalvia Antonio, Szöke Andrei, Arango Celso, Bernardo MiquelORCID, Bobes JulioORCID, Del Ben Cristina MartaORCID, Menezes Paulo RossiORCID, Llorca Pierre-MichelORCID, Santos Jose Luis, Sanjuán Julio, Arrojo Manuel, Tortelli Andrea, Velthorst Eva, Berendsen Steven, de Haan Lieuwe, Rutten Bart P. F.ORCID, Lynskey Michael T., Freeman Tom P., Kirkbride James B.ORCID, Sham Pak C., O’Donovan Michael C.ORCID, Cardno Alastair G., Vassos EvangelosORCID, van Os Jim, Morgan Craig, Murray Robin M.ORCID, Lewis Cathryn M.ORCID, Di Forti Marta, Hubbard Kathryn, Beards Stephanie, Stilo Simona A., Parellada Mara, Fraguas David, Castro Marta Rapado, Andreu-Bernabeu Álvaro, López Gonzalo, Matteis Mario, González Emiliano, Durán-Cutilla Manuel, Díaz-Caneja Covadonga M., Cuadrado Pedro, Rodríguez Solano José Juan, Carracedo Angel, Costas Javier, Sánchez Emilio, Amoretti Silvia, Lorente-Rovira Esther, Garcia-Portilla Paz, Jiménez-López Estela, Franke Nathalie, van Dam Daniella, Termorshuizen Fabian, Franke Nathalie, van der Ven Elsje, Messchaart Elles, Leboyer Marion, Schürhoff Franck, Jamain Stéphane, Baudin Grégoire, Ferchiou Aziz, Pignon Baptiste, Richard Jean-Romain, Charpeaud Thomas, Tronche Anne-Marie, Frijda Flora, Marrazzo Giovanna, Sideli Lucia, Sartorio Crocettarachele, Seminerio Fabio, Loureiro Camila Marcelino, Shuhama Rosana, Ruggeri Mirella, Bonetto Chiara, Cristofalo Doriana, Berardi Domenico, Seri Marco, D’Andrea Giuseppe,
Abstract
AbstractDiagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis use on the transdiagnostic expression of psychosis. We analysed first-episode psychosis patients (FEP) and controls, generating transdiagnostic dimensions of psychotic symptoms and experiences using item response bi-factor modelling. Linear regression was used to test the associations between these dimensions and SZ-PRS, as well as the combined effect of SZ-PRS and cannabis use on the dimensions of positive psychotic symptoms and experiences. We found associations between SZ-PRS and (1) both negative (B = 0.18; 95%CI 0.03–0.33) and positive (B = 0.19; 95%CI 0.03–0.35) symptom dimensions in 617 FEP patients, regardless of their categorical diagnosis; and (2) all the psychotic experience dimensions in 979 controls. We did not observe associations between SZ-PRS and the general and affective dimensions in FEP. Daily and current cannabis use were associated with the positive dimensions in FEP (B = 0.31; 95%CI 0.11–0.52) and in controls (B = 0.26; 95%CI 0.06–0.46), over and above SZ-PRS. We provide evidence that genetic liability to schizophrenia and cannabis use map onto transdiagnostic symptom dimensions, supporting the validity and utility of the dimensional representation of psychosis. In our sample, genetic liability to schizophrenia correlated with more severe psychosis presentation, and cannabis use conferred risk to positive symptomatology beyond the genetic risk. Our findings support the hypothesis that psychotic experiences in the general population have similar genetic substrates as clinical disorders.
Funder
Guarantors of Brain RCUK | Medical Research Council
Publisher
Springer Science and Business Media LLC
Subject
Biological Psychiatry,Cellular and Molecular Neuroscience,Psychiatry and Mental health
Reference82 articles.
1. Zachar P, Kendler KS. ThE PHILOSOPHY OF NOSology. Annu Rev Clin Psychol. 2017;13:49–71. 2. Kendell R, Jablensky A. Distinguishing between the validity and utility of psychiatric diagnoses. Am J Psychiatry. 2003;160:4–12. 3. Brockington IF, Kendell RE, Kellett JM, Curry SH, Wainwright S. Trials of lithium, chlorpromazine and amitriptyline in schizoaffective patients. Br J Psychiatry. 1978;133:162–8. 4. Cross-Disorder Group of the Psychiatric Genomics Consortium. Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell 2019;179:1469–82.e1411. 5. Linscott RJ, van Os J. Systematic reviews of categorical versus continuum models in psychosis: evidence for discontinuous subpopulations underlying a psychometric continuum. Implications for DSM-V, DSM-VI, and DSM-VII. Annu Rev Clin Psychol. 2010;6:391–419.
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