Purine-Type Compounds Induce Microtubule Fragmentation and Lung Cancer Cell Death through Interaction with Katanin

Author:

Kuo Ting-Chun1,Li Ling-Wei2,Pan Szu-Hua134,Fang Jim-Min2,Liu Jyung-Hurng5678,Cheng Ting-Jen9,Wang Chia-Jen1011,Hung Pei-Fang10,Chen Hsuan-Yu12,Hong Tse-Ming13,Hsu Yuan-Ling3,Wong Chi-Huey9,Yang Pan-Chyr1415

Affiliation:

1. Ph.D. Program in Translational Medicine, National Taiwan University and Academia Sinica, Taipei, Taiwan

2. Department of Chemistry, National Taiwan University, Taipei 106, Taiwan

3. Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei 100, Taiwan

4. Genome and Systems Biology Degree Program, National Taiwan University and Academia Sinica, Taipei 106, Taiwan

5. Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan

6. Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan

7. Agricultural Biotechnology Center, National Chung Hsing University, Taichung 402, Taiwan

8. Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan

9. Genomics Research Center, Academia Sinica, Taipei 115, Taiwan

10. Department of Internal Medicine, National Taiwan University College of Medicine, Taipei 100, Taiwan

11. Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial HospitalTaipei 105, Taiwan

12. Institute of Statistical Science, Academia Sinica, Taipei 115, Taiwan

13. Institute of Clinical Medicine, National Cheng Kung University College of Medicine, Tainan 701, Taiwan

14. Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan

15. NTU Center for Genomic Medicine, National Taiwan University, Taipei 100, Taiwan

Funder

National Science Council

Academia Sinica

National Taiwan University

Ministry of Science and Technology, Taiwan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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