Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery

Author:

Davies Thomas G.1,Wixted William E.2,Coyle Joseph E.1,Griffiths-Jones Charlotte1,Hearn Keisha1,McMenamin Rachel1,Norton David1,Rich Sharna J.1,Richardson Caroline1,Saxty Gordon1,Willems Henriëtte M. G.1,Woolford Alison J.-A.1,Cottom Joshua E.3,Kou Jen-Pyng2,Yonchuk John G.2,Feldser Heidi G.2,Sanchez Yolanda2,Foley Joseph P.2,Bolognese Brian J.2,Logan Gregory2,Podolin Patricia L.2,Yan Hongxing2,Callahan James F.2,Heightman Tom D.1,Kerns Jeffrey K.2

Affiliation:

1. Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K.

2. GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States

3. GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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