Discovery of Novel Dihydrothiopyrano[4,3-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs with Significantly Reduced hERG Inhibitory Activity and Improved Resistance Profiles-Reference-Cited by-同舟云学术

Discovery of Novel Dihydrothiopyrano[4,3-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs with Significantly Reduced hERG Inhibitory Activity and Improved Resistance Profiles

Published:2021-08-25 Issue:18 Volume:64 Page:13658-13675
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Zhao¹,Zalloum Waleed A.²^ORCID,Wang Wenbo¹,Jiang Xiangyi¹,De Clercq Erik³^ORCID,Pannecouque Christophe³,Kang Dongwei¹⁴^ORCID,Zhan Peng¹⁴^ORCID,Liu Xinyong¹⁴^ORCID

Affiliation:

1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, PR China

2. Department of Pharmacy, Faculty of Health Science, American University of Madaba, P.O. Box 2882, Amman 11821, Jordan

3. Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K. U. Leuven, Herestraat 49 Postbus 1043 (09.A097), Leuven B-3000, Belgium

4. China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, Jinan, Shandong 250012, PR China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Shandong Provincial Key research and development project

Foreign cultural and educational experts Project

Science Foundation for Excellent Young Scholars of Shandong Province

Qilu Young Scholars Program of Shandong University

Taishan Scholar Program, Shandong Province

Science Foundation for Outstanding Young Scholars of Shandong Province

Publisher

American Chemical Society (ACS)

Subject