Discovery and Evaluation of 3-Quinoxalin Urea Derivatives as Potent, Selective, and Orally Available ATM Inhibitors Combined with Chemotherapy for the Treatment of Cancer via Goal-Oriented Molecule Generation and Virtual Screening

Author:

Deng Dexin1,Yang Yingxue1,Zou Yurong2,Liu Kongjun1,Zhang Chufeng1,Tang Minghai1,Yang Tao1ORCID,Chen Yong1,Yuan Xue1,Guo Yong1,Zhang Shunjie1,Si Wenting1,Peng Bin1,Xu Qing1,He Wen1,Xu Dingguo2ORCID,Xiang Mingli1,Chen Lijuan13ORCID

Affiliation:

1. Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu610041, China

2. MOE Key Laboratory of Green Chemistry and Technology, College of Chemistry, Sichuan University, Chengdu, Sichuan610064, P.R. China

3. Chengdu Zenitar Biomedical Technology Co., Ltd., Chengdu610041, China

Funder

West China Hospital, Sichuan University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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