Novel 2-substituted-quinoxaline analogs with potential antiproliferative activity against breast cancer: insights into cell cycle arrest, topoisomerase II, and EGFR activity-Reference-Cited by-同舟云学术

Novel 2-substituted-quinoxaline analogs with potential antiproliferative activity against breast cancer: insights into cell cycle arrest, topoisomerase II, and EGFR activity

Published:2023 Issue:47 Volume:13 Page:33080-33095
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Salem Manar G.¹^ORCID,Abu El-ata Sara A.²,Elsayed Elsherbiny H.²,Mali Suraj N.³^ORCID,Alshwyeh Hussah Abdullah⁴⁵,Almaimani Ghassan⁶,Almaimani Riyad A.⁷^ORCID,Almasmoum Hussain A.⁸,Altwaijry Najla⁹^ORCID,Al-Olayan Ebtesam¹⁰,Saied Essa M.¹¹¹²^ORCID,Youssef Mohamed F.¹³^ORCID

Affiliation:

1. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt

2. Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt

3. Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Ranchi 835215, India

4. Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia

5. Basic & Applied Scientific Research Centre, Imam Abdulrahman Bin Faisal University, PO Box 1982, Dammam 31441, Saudi Arabia

6. Department of Surgery, Faculty of Medicine, Umm Al-Qura University, Al Abdeyah, PO Box 7607, Makkah, Saudi Arabia

7. Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Al Abdeyah, PO Box 7607, Makkah, Saudi Arabia

8. Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Al Abdeyah, PO Box 7607, Makkah, Saudi Arabia

9. Department of Pharmaceutical Sciences, Princess Nourah Bint Abdulrahman University, PO Box 84428, Riyadh 11671, Saudi Arabia

10. Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia

11. Department of Chemistry (Biochemistry Division), Faculty of Science, Suez Canal University, Ismailia 41522, Egypt

12. Institute for Chemistry, Humboldt Universität zu Berlin, Brook-Taylor-Str. 2, 12489 Berlin, Germany

13. Department of Chemistry (Organic Chemistry Division), Faculty of Science, Suez Canal University, Ismailia 41522, Egypt

Abstract

We reported a novel 2-coumarin-substituted-quinoxaline analogue (3b) with potential antiproliferative activity against MCF-7 breast cancer cells by inducing cell cycle arrest and targeting topoisomerase II, and EGFR activity.

Funder

Princess Nourah Bint Abdulrahman University

King Saud University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA06189B

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