Using a Function-First “Scout Fragment”-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes

Author:

Ramsey Jared R.12ORCID,Shelton Patrick M. M.2,Heiss Tyler K.2,Olinares Paul Dominic B.3,Vostal Lauren E.12ORCID,Soileau Heather12ORCID,Grasso Michael2,Casebeer Sara W.2,Adaniya Stephanie4,Miller Michael5,Sun Shan5,Huggins David J.56,Myers Robert W.5ORCID,Chait Brian T.3,Vinogradova Ekaterina V.14,Kapoor Tarun M.12ORCID

Affiliation:

1. Tri-Institutional PhD Program in Chemical Biology, New York, New York 10021, United States

2. Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, New York 10065, United States

3. Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York 10065, United States

4. Laboratory of Chemical Immunology and Proteomics, The Rockefeller University, New York, New York 10065, United States

5. Sanders Tri-Institutional Therapeutics Discovery Institute, New York, New York 10065, United States

6. Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York 10021, United States

Funder

Takeda Pharmaceutical Company

Achelis and Bodman Foundation

Stavros Niarchos Foundation

Rockefeller University

National Institute of General Medical Sciences

Robertson Foundation

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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