A Combined Ligand- and Structure-Based Virtual Screening To Identify Novel NaV1.2 Blockers: In Vitro Patch Clamp Validation and In Vivo Anticonvulsant Activity-Reference-Cited by-同舟云学术

A Combined Ligand- and Structure-Based Virtual Screening To Identify Novel NaV1.2 Blockers: In Vitro Patch Clamp Validation and In Vivo Anticonvulsant Activity

Published:2023-11-02 Issue:22 Volume:63 Page:7083-7096
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Llanos Manuel A.¹^ORCID,Enrique Nicolás²^ORCID,Esteban-López Vega³⁴,Scioli-Montoto Sebastian¹,Sánchez-Benito David³⁴^ORCID,Ruiz María E.¹,Milesi Veronica²,López Dolores E.³⁴^ORCID,Talevi Alan¹^ORCID,Martín Pedro²,Gavernet Luciana¹^ORCID

Affiliation:

1. Laboratory of Bioactive Compounds Research and Development (LIDeB), Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata (UNLP), La Plata B1900ADU, Argentina

2. Facultad de Ciencias Exactas, Departamento de Ciencias Biológicas, Instituto de Estudios Inmunológicos y Fisiopatológicos (IIFP), UNLP, CONICET, asociado CIC PBA, La Plata B1900BJW, Buenos Aires, Argentina

3. Institute for Neuroscience of Castilla y León (INCyL), University of Salamanca, Salamanca 37008, Spain

4. Institute for Biomedical Research of Salamanca (IBSAL), Salamanca 37007, Spain

Funder

European Regional Development Fund

Universidad Nacional de La Plata

Agencia Nacional de Promoci?n de la Investigaci?n, el Desarrollo Tecnol?gico y la Innovaci?n

Junta de Castilla y Le?n

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.3c00645

Reference56 articles.

1. From Ionic Currents to Molecular Mechanisms

2. Distribution and function of voltage-gated sodium channels in the nervous system

3. Voltage-gated ion channels and gating modifier toxins

4. Voltage-Gated Sodium Channel β Subunits and Their Related Diseases

5. Recent progress in sodium channel modulators for pain