Assessing the Effectiveness of Eslicarbazepine Acetate in Reducing Audiogenic Reflex Seizures in the GASH/Sal Model of Epilepsy

Author:

Gonçalves-Sánchez Jaime123ORCID,Ramírez-Santos Thomas3,López Dolores E.123ORCID,Gonçalves-Estella Jesús M.24ORCID,Sancho Consuelo235ORCID

Affiliation:

1. Department of Cell Biology and Pathology, School of Medicine, University of Salamanca, 37007 Salamanca, Spain

2. Institute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain

3. Institute of Neuroscience of Castilla y León, 37007 Salamanca, Spain

4. Department of Surgery, School of Medicine, University of Salamanca, 37007 Salamanca, Spain

5. Department of Physiology and Pharmacology, School of Medicine, University of Salamanca, 37007 Salamanca, Spain

Abstract

Eslicarbazepine acetate (ESL) is a third-generation antiepileptic drug indicated as monotherapy for adults with newly diagnosed epilepsy and as adjunctive therapy for the treatment of partial seizures. Our aim was to assess the effectiveness and safety of both acute and repeated ESL administration against reflex audiogenic seizures, as shown by the Genetic Audiogenic Seizures Hamster from Salamanca (GASH/Sal). Animals were subject to the intraperitoneal administration of ESL, applying doses of 100, 150 and 200 mg/kg for the acute study, whereas a daily dose of 100 mg/kg was selected for the subchronic study, which lasted 14 days. In both studies, the anticonvulsant effect of the therapy was evaluated using neuroethological methods. To assess the safety of the treatment, behavioral tests were performed, hematological and biochemical liver profiles were obtained, and body weight was monitored. In addition, the ESL levels in blood were measured after the acute administration of a 200 mg/kg dose. Treatment with ESL caused a reduction in seizure severity. No statistically significant differences were detected between the selected doses or between the acute or repeated administration of the drug. To summarize, the intraperitoneal administration of ESL is safe and shows an anticonvulsant effect in the GASH/Sal.

Funder

University of Salamanca Research grant

Spanish Government

Publisher

MDPI AG

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