Structure-Based Discovery of a Novel Class of Small-Molecule Pure Antagonists of Integrin αVβ3

Author:

Sen Soumyo1,Spasic Aleksandar1,Sinha Anjana2,Wang Jialing3,Bush Martin3,Li Jihong2,Nešić Dragana2,Zhou Yuchen1,Angiulli Gabriella3,Morgan Paul1,Salas-Estrada Leslie1,Takagi Junichi4,Walz Thomas3ORCID,Coller Barry S.2ORCID,Filizola Marta1ORCID

Affiliation:

1. Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1677, New York, New York10029, United States

2. Allen and Frances Adler Laboratory of Blood and Vascular Biology, The Rockefeller University, 1230 York Avenue, P.O. Box 309, New York, New York10065, United States

3. Laboratory of Molecular Electron Microscopy, The Rockefeller University, 1230 York Avenue, P.O. Box 219, New York, New York10065, United States

4. Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka565-0871, Japan

Funder

National Center for Advancing Translational Sciences

National Heart, Lung, and Blood Institute

Robertson Therapeutic Discovery Fund, Rockefeller University

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

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