Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease-Reference-Cited by-同舟云学术

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

Published:2014-01-16 Issue:3 Volume:123 Page:377-390
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Belcher John D.¹,Chen Chunsheng¹,Nguyen Julia¹,Milbauer Liming¹,Abdulla Fuad¹,Alayash Abdu I.²,Smith Ann³,Nath Karl A.⁴,Hebbel Robert P.¹,Vercellotti Gregory M.¹

Affiliation:

1. Division of Hematology, Oncology and Transplantation, Vascular Biology Center, University of Minnesota, Minneapolis, MN;

2. Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD;

3. Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri–Kansas City, Kansas City, MO; and

4. Nephrology Research Unit, Mayo Clinic/Foundation, Rochester, MN

Abstract

Key Points Heme, released from hemoglobin, elicits vaso-occlusion in transgenic sickle mice via endothelial TLR4 signaling. Heme/TLR4 signaling activates NF-κB and triggers vaso-occlusion through Weibel-Palade body degranulation and adhesion molecule expression.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/3/377/1377429/377.pdf

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