Selectivity Determinants of Inhibitor Binding to Human 20α-Hydroxysteroid Dehydrogenase: Crystal Structure of the Enzyme in Ternary Complex with Coenzyme and the Potent Inhibitor 3,5-Dichlorosalicylic Acid
Author:
Affiliation:
1. Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia, Laboratory of Biochemistry, Gifu Pharmaceutical University, Mitahora-higashi, Gifu 502-8585, Japan
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm8003575
Reference35 articles.
1. Hydroxysteroid dehydrogenases and pre-receptor regulation of steroid hormone action
2. Comparative anatomy of the aldo–keto reductase superfamily
3. The aldo-keto reductase (AKR) superfamily: an update
4. Short-chain dehydrogenases/reductases (SDR): the 2002 update
5. Structure and function of 3α-hydroxysteroid dehydrogenase
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