Integrative Molecular Structure Elucidation and Construction of an Extended Metabolic Pathway Associated with an Ancient Innate Immune Response in COVID-19 Patients

Author:

Sala Samuele1,Nitschke Philipp1ORCID,Masuda Reika1,Gray Nicola1ORCID,Lawler Nathan G.1ORCID,Wood James M.23ORCID,Buckler Joshua N.2ORCID,Berezhnoy Georgy4,Bolaños Jose5,Boughton Berin A.1ORCID,Lonati Caterina6,Rössler Titus4,Singh Yogesh7,Wilson Ian D.8ORCID,Lodge Samantha1ORCID,Morillon Aude-Claire1,Loo Ruey Leng1ORCID,Hall Drew1,Whiley Luke1ORCID,Evans Gary B.23,Grove Tyler L.9ORCID,Almo Steven C.9,Harris Lawrence D.23ORCID,Holmes Elaine18ORCID,Merle Uta10,Trautwein Christoph4ORCID,Nicholson Jeremy K.111ORCID,Wist Julien1512ORCID

Affiliation:

1. The Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth WA6150, Australia

2. Ferrier Research Institute, Victoria University of Wellington, Wellington 6012, New Zealand

3. The Maurice Wilkins Centre for Molecular Biodiscovef Wellington, Welry, The University of Auckland, Auckland 1010, New Zealand

4. Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University Hospital Tübingen, 72074 Tübingen, Germany

5. Chemistry Department, Universidad del Valle, Cali 76001, Colombia

6. Center for Preclinical Research, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy

7. Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen, 72074 Tübingen, Germany

8. Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College, Burlington Danes Building, Du Cane Road, London W12 0NN, U.K.

9. Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States

10. Department of Internal Medicine IV, University Hospital Heidelberg, 69120 Heidelberg, Germany

11. Institute of Global Health Innovation, Faculty of Medicine, Imperial College London, Level 1, Faculty Building, South Kensington Campus, London SW7 2NA, U.K.

12. Faculty of Medicine, Department of Metabolism, Digestion and Reproduction, Division of Digestive Diseases at Imperial College, London SW7 2AZ, U.K.

Funder

Ministry of Business, Innovation and Employment

Spinnaker Health Research Foundation

Department of Health and Aged Care, Australian Government

Instituto Colombiano de Cr?dito Educativo y Estudios T?cnicos en el Exterior

Australian Research Council

Department of Jobs, Tourism, Science and Innovation, Government of Western Australia

McCusker Charitable Foundation

Ministerio de Ciencia, Tecnolog?a e Innovaci?n

Pontificia Universidad Javeriana

Ministerio de Comercio, Industria y Turismo

World Bank Group

Ministerio de Educaci?n Nacional, Colombia

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,Biochemistry

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