Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease

Author:

Bergamaschi Laura,Mescia FedericaORCID,Turner Lorinda,Hanson Aimee L.ORCID,Kotagiri Prasanti,Dunmore Benjamin J.,Ruffieux HélèneORCID,De Sa AlokaORCID,Huhn Oisín,Morgan Michael D.ORCID,Gerber Pehuén Pereyra,Wills Mark R.,Baker Stephen,Calero-Nieto Fernando J.,Doffinger Rainer,Dougan Gordon,Elmer Anne,Goodfellow Ian G.,Gupta Ravindra K.,Hosmillo MyraORCID,Hunter Kelvin,Kingston NathalieORCID,Lehner Paul J.,Matheson Nicholas J.ORCID,Nicholson Jeremy K.ORCID,Petrunkina Anna M.,Richardson Sylvia,Saunders Caroline,Thaventhiran James E.D.ORCID,Toonen Erik J.M.,Weekes Michael P.,Göttgens Berthold,Toshner Mark,Hess Christoph,Bradley John R.ORCID,Lyons Paul A.,Smith Kenneth G.C.

Funder

NHSBT

Fondation Botnar

MRC

Wellcome Trust

Royal Australasian College of Physicians

The McCusker Charitable Foundation

Publisher

Elsevier BV

Subject

Infectious Diseases,Immunology,Immunology and Allergy

Reference81 articles.

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3. Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans;Arunachalam;Science,2020

4. Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics;Banchereau;Annu. Rev. Immunol.,2017

5. The spectrum of T cell metabolism in health and disease;Bantug;Nat. Rev. Immunol.,2018

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