New Methodology for Determining Plasma Protein Binding Kinetics Using an Enzyme Reporter Assay Coupling with High-Resolution Mass Spectrometry
Author:
Affiliation:
1. Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California 94080, United States
Publisher
American Chemical Society (ACS)
Subject
Analytical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.2c04864
Reference34 articles.
1. Incorporating Receptor Theory in Mechanism-Based Pharmacokinetic-Pharmacodynamic (PK-PD) Modeling
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3. Free Drug Theory – No Longer Just a Hypothesis?
4. Rational Use of Plasma Protein and Tissue Binding Data in Drug Design
5. Plasma protein binding: From discovery to development
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