Straightforward Access to Spisulosine and 4,5-Dehydrospisulosine Stereoisomers: Probes for Profiling Ceramide Synthase Activities in Intact Cells

Author:

Abad José Luis1,Nieves Ingrid1,Rayo Pedro1,Casas Josefina1,Fabriàs Gemma1,Delgado Antonio12

Affiliation:

1. Consejo Superior de Investigaciones Científicas (CSIC), Institut de Química Avançada de Catalunya (IQAC−CSIC), Research Unit on Bioactive Molecules (RUBAM), Jordi Girona 18-26, 08034 Barcelona, Spain

2. Universidad de Barcelona (UB), Facultad de Farmacia, Unidad de Química Farmacéutica (Unidad Asociada al CSIC), Avda. Joan XXIII s/n, 08028 Barcelona, Spain

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Reference46 articles.

1. Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease

2. The marine compound spisulosine, an inhibitor of cell proliferation, promotes the disassembly of actin stress fibers

3. Rinehart, K. L.; Fregeau, N. L.; Warwick, R. A.; Garcia Gravalos, D.; Avila, J.; Faircloth, G. T.Spisulosine compounds having antitumor activity. PCT WO9952521 A1 19991021, 1999.

4. Rinehart, K. L.; Warwick, R. A.; Avila, J.; Fregeau, G. N. L.; Garcia, G. D.; Faircloth, G. T.Antitumor spisulosine compounds. US 6800661 B1 20041005, 2004.

5. Acylation of Naturally Occurring and Synthetic 1-Deoxysphinganines by Ceramide Synthase

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