Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition-Reference-Cited by-同舟云学术

Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition

Published:2016-11-10 Issue:12 Volume:11 Page:3442-3451
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Telliez Jean-Baptiste¹,Dowty Martin E.²,Wang Lu¹,Jussif Jason¹,Lin Tsung¹,Li Li¹,Moy Erick¹,Balbo Paul¹,Li Wei¹,Zhao Yajuan¹,Crouse Kimberly¹,Dickinson Caitlyn¹,Symanowicz Peter¹,Hegen Martin¹,Banker Mary Ellen³,Vincent Fabien³,Unwalla Ray⁴,Liang Sidney⁵,Gilbert Adam M.⁵,Brown Matthew F.⁵,Hayward Matthew⁵,Montgomery Justin⁵,Yang Xin²,Bauman Jonathan²,Trujillo John I.⁵,Casimiro-Garcia Agustin⁴,Vajdos Felix F.⁵,Leung Louis²,Geoghegan Kieran F.⁵,Quazi Amira¹,Xuan Dejun¹,Jones Lyn⁴,Hett Erik⁴,Wright Katherine²,Clark James D.¹,Thorarensen Atli⁴

Affiliation:

1. Inflammation and Immunology, Pfizer Worldwide R&D, 610 Main Street, Cambridge, Massachusetts 02139, United States

2. Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide R&D, Eastern Point Road, Groton, Connecticut 06340, United States

3. Primary Pharmacology Group, Pfizer Worldwide R&D, Eastern Point Road, Groton, Connecticut 06340, United States

4. Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, Massachusetts 02139, United States

5. Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, Eastern Point Road, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.6b00677

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