New insights into the regulation of T cells by γc family cytokines
Author:
Publisher
Springer Science and Business Media LLC
Subject
Energy Engineering and Power Technology,Fuel Technology
Link
http://www.nature.com/articles/nri2580.pdf
Reference149 articles.
1. Leonard, W. J. Cytokines and immunodeficiency diseases. Nature Rev. Immunol. 1, 200–208 (2001).
2. Spolski, R. & Leonard, W. J. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu. Rev. Immunol. 26, 57–79 (2008).
3. Takeshita, T. et al. Cloning of the γ chain of the human IL-2 receptor. Science 257, 379–382 (1992).
4. Wang, X., Lupardus, P., Laporte, S. L. & Garcia, K. C. Structural biology of shared cytokine receptors. Annu. Rev. Immunol. 27, 29–60 (2009). A comprehensive review that details the structures of cytokine receptor families that contain gp130, γ c or β c , highlights structural similarities and differences between these families, and discusses their abilities to bind ligands and mediate signalling.
5. Noguchi, M. et al. Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 73, 147–157 (1993). This paper showed that mutations in IL2RG result in XSCID in humans and therefore revealed crucial roles for γ c in the development of T cells and NK cells. The authors correctly speculated that γ c has important roles beyond the action of IL-2.
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