Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers

Author:

Ye Ling F.1,Chaudhary Kunal R.2,Zandkarimi Fereshteh1,Harken Andrew D.3,Kinslow Connor J.2,Upadhyayula Pavan S.4,Dovas Athanassios5,Higgins Dominique M.4,Tan Hui1,Zhang Yan1,Buonanno Manuela3,Wang Tony J. C.26,Hei Tom K.26,Bruce Jeffrey N.4,Canoll Peter D.56,Cheng Simon K.26,Stockwell Brent R.167ORCID

Affiliation:

1. Department of Biological Sciences, Columbia University, New York, New York 10027, United States

2. Department of Radiation Oncology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York 10032, United States

3. Radiological Research Accelerator Facility, Center for Radiological Research, Columbia University, Irvington, New York 10533, United States

4. Department of Neurological Surgery, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York 10032, United States

5. Departments of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, 1130 St. Nicholas Ave Rm.1001, New York, New York 10032, United States

6. Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York 10032, United States

7. Department of Chemistry, Columbia University, New York, New York 10027, United States

Funder

National Cancer Institute

National Institute of Neurological Disorders and Stroke

National Institute of Biomedical Imaging and Bioengineering

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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