The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition

Author:

Koller Timm O.1ORCID,Scheid Ullrich2,Kösel Teresa3,Herrmann Jennifer24ORCID,Krug Daniel254,Boshoff Helena I. M.6ORCID,Beckert Bertrand1,Evans Joanna C.7,Schlemmer Jan24,Sloan Becky6,Weiner Danielle M.6,Via Laura E.6,Moosa Atica7,Ioerger Thomas R.8,Graf Michael1,Zinshteyn Boris9,Abdelshahid Maha1,Nguyen Fabian1,Arenz Stefan1,Gille Franziska3,Siebke Maik310,Seedorf Tim3,Plettenburg Oliver310ORCID,Green Rachel9,Warnke Anna-Luisa310,Ullrich Joachim11,Warrass Ralf11,Barry Clifton E.6,Warner Digby F.7ORCID,Mizrahi Valerie7ORCID,Kirschning Andreas3ORCID,Wilson Daniel N.1ORCID,Müller Rolf254ORCID

Affiliation:

1. Institute for Biochemistry and Molecular Biology, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany

2. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarland University Campus, 66123 Saarbrücken, Germany

3. Leibniz Universität Hannover, Institute of Organic Chemistry and Center for Biomolecular Drug Research (BMWZ), Schneiderberg 1B, 30167 Hannover, Germany

4. German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, 38124 Braunschweig, Germany

5. Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany

6. Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, United States

7. SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, University of Cape Town, Rondebosch 7700, South Africa

8. Department of Computer Science and Engineering, Texas A&M University, College Station, Texas 77843, United States

9. Department of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, Maryland 21205, United States; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States

10. Institute of Medicinal Chemistry, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany

11. MSD Animal Health Innovation GmbH, Zur Propstei, 55270 Schwabenheim, Germany

Funder

Medical Research Council

Helmholtz-Gemeinschaft

National Institute of Allergy and Infectious Diseases

Deutsche Forschungsgemeinschaft

Bill and Melinda Gates Foundation

Horizon 2020 Framework Programme

National Research Foundation

iNEXT Consortium

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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