Characterization of a Radical SAM Oxygenase for the Ether Crosslinking in Darobactin Biosynthesis-Reference-Cited by-同舟云学术

Characterization of a Radical SAM Oxygenase for the Ether Crosslinking in Darobactin Biosynthesis

Published:2022-10-04 Issue:41 Volume:144 Page:18876-18886
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Nguyen Hai¹,Made Kresna I Dewa²,Böhringer Nils²³,Ruel Jeremie⁴,Mora Eugenio de la⁴,Kramer Jil-Christine²,Lewis Kim⁵,Nicolet Yvain⁴^ORCID,Schäberle Till F.²³⁶^ORCID,Yokoyama Kenichi¹⁷^ORCID

Affiliation:

1. Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27710, United States

2. Institute for Insect Biotechnology, Justus-Liebig-University of Giessen, Ohlebergsweg 12, 35392 Giessen, Germany

3. German Center for Infection Research (DZIF), Partner Site Giessen-Marburg-Langen, 35392 Giessen, Germany

4. University of Grenoble Alpes, CEA, CNRS, IBS, Metalloproteins Unit, F-38000 Grenoble, France

5. Antimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts 02115, United States

6. Department of Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology, Ohlebergsweg 12, 35392 Giessen, Germany

7. Department of Chemistry, Duke University, Durham, North Carolina 27710, United States

Funder

Agence Nationale de la Recherche

Bundesministerium f?r Bildung und Forschung

Deutscher Akademischer Austauschdienst

National Institute of Allergy and Infectious Diseases

Hessisches Ministerium f?r Wissenschaft und Kunst

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.2c05565

Reference27 articles.

1. Author Correction: A new antibiotic selectively kills Gram-negative pathogens

2. The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase

3. Optimization of heterologous Darobactin A expression and identification of the minimal biosynthetic gene cluster

4. Improved broad-spectrum antibiotics against Gram-negative pathogens via darobactin biosynthetic pathway engineering

5. Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods

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