Improved broad-spectrum antibiotics against Gram-negative pathogens via darobactin biosynthetic pathway engineering-Reference-Cited by-同舟云学术

Improved broad-spectrum antibiotics against Gram-negative pathogens via darobactin biosynthetic pathway engineering

Published:2021 Issue:35 Volume:12 Page:11882-11893
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Groß Sebastian¹²³^ORCID,Panter Fabian¹²³⁴,Pogorevc Domen¹²³,Seyfert Carsten E.¹²³,Deckarm Selina¹²³,Bader Chantal D.¹²³,Herrmann Jennifer¹²³,Müller Rolf¹²³⁴^ORCID

Affiliation:

1. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Saarland University Campus, 66123 Saarbrücken, Germany

2. Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany

3. DZIF – German Centre for Infection Research, Partner site Hannover-Braunschweig, Germany

4. Helmholtz International Lab for Anti-Infectives, Campus E8 1, 66123 Saarbrücken, Germany

Abstract

Heterologous expression of a synthetically engineered darobactin gene cluster in E. coli yields new darobactin derivatives with improved anti-Gram-negative activity. Targeted gene deletions provide first insights into biosynthetic steps.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC02725E

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