Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble-Reference-Cited by-同舟云学术

Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble

Published:2018-04-30 Issue:23 Volume:140 Page:7256-7266
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Buller Andrew R.¹²^ORCID,van Roye Paul²,Cahn Jackson K. B.³,Scheele Remkes A.²,Herger Michael²,Arnold Frances H.²^ORCID

Affiliation:

1. Department of Chemistry, University of Wisconsin—Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States

2. Division of Chemistry and Chemical Engineering, California Institute of Technology, 210-41, 1200 East California Boulevard, Pasadena, California 91125, United States

3. Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, Zurich 8093, Switzerland

Funder

Gordon and Betty Moore Foundation

Sanofi

National Institute of General Medical Sciences

Backer Foundation

Beckman Institute, California Institute of Technology

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.8b03490

Reference61 articles.

1. Engineering the third wave of biocatalysis

2. Role of Biocatalysis in Sustainable Chemistry

3. The ensemble nature of allostery

4. An Iterative, Bimodular Nonribosomal Peptide Synthetase that Converts Anthranilate and Tryptophan into Tetracyclic Asperlicins

5. An Engineered Tryptophan Synthase Opens New Enzymatic Pathways to β-Methyltryptophan and Derivatives

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