Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481

Author:

Boy Kenneth M.1ORCID,Guernon Jason M.1,Zuev Dmitry S.1,Xu Li1,Zhang Yunhui1,Shi Jianliang1,Marcin Lawrence R.1ORCID,Higgins Mendi A.1,Wu Yong-Jin1ORCID,Krishnananthan Subramaniam1,Li Jianqing1ORCID,Trehan Ashok1,Smith Daniel1,Toyn Jeremy H.1,Meredith Jere E.1,Burton Catherine R.1,Kimura S. Roy1,Zvyaga Tatyana1,Zhuo Xiaoliang1,Lentz Kimberley A.1,Grace James E.1,Denton Rex1,Morrison John S.1,Mathur Arvind2,Albright Charles F.1,Ahlijanian Michael K.1,Olson Richard E.1,Thompson Lorin A.1,Macor John E.1

Affiliation:

1. Bristol-Myers Squibb, Wallingford, Connecticut 06492, United States

2. Bristol-Myers Squibb, Princeton, New Jersey 08543, United States

Funder

Bristol-Myers Squibb

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference28 articles.

1. 2018 Alzheimer's disease facts and figures

2. Merck press release, February 13, 2018. http://investors.merck.com/news/press-release-details/2018/Merck-Announces-Discontinuation-of-APECS-Study-Evaluating-Verubecestat-MK-8931-for-the-Treatment-of-People-with-Prodromal-Alzheimers-Disease/default.aspx, (accessed August 1, 2018).

3. BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

4. Lilly/Astra-Zeneca press release, June 12, 2018. https://www.astrazeneca.com/media-centre/press-releases/2018/update-on-phase-iii-clinical-trials-of-lanabecestat-for-alzheimers-disease-12062018.html, (accessed August 1, 2018).

5. The Many Substrates of Presenilin/γ-Secretase

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