T–cell memory: lessons from Epstein–Barr virus infection in man

Author:

Rickinson A. B.1,Callan M. F. C.2,Annels N. E.1

Affiliation:

1. CRC Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

2. institute for Molecular Medicine, John Radcliffe Hospital, Oxford 0X3 9DU, UK

Abstract

Epstein–Barr virus offers an ideal opportunity to follow the human T–cell response to a virus infection over time from its acute primary phase, as seen in infectious mononucleosis patients, into the memory phase that accompanies life–long virus persistence. Here we review recent evidence on the development and maturation of cytotoxic T–cell memory using this viral system.

Publisher

The Royal Society

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

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