Effect of dorsolateral prefrontal cortex structural measures on neuroplasticity and response to paired-associative stimulation in Alzheimer’s dementia

Author:

Naveed K.12ORCID,Rashidi-Ranjbar N.123,Kumar S.1245,Zomorrodi R.14,Blumberger D. M.145,Fischer C. E.123,Sanches M.6,Mulsant B. H.1245,Pollock B. G.145,Voineskos A. N.145,Rajji T. K.1245

Affiliation:

1. Temerty Faculty of Medicine, University of Toronto, 1 King’s College Cir , Toronto, Ontario M5S 1A8, Canada

2. Toronto Dementia Research Alliance, University of Toronto, 250 College Street , Toronto, Ontario M5T 1R8, Canada

3. Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, 209 Victoria Street , Toronto, Ontario M5B 1T8, Canada

4. Campbell Family Mental Health Research Institute, CAMH, 479 Spadina Avenue , Toronto, Ontario M5S 2S1, Canada

5. Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, 250 College Street , Toronto, Ontario M5T 1R8, Canada

6. Biostatistics Core, Centre for Addiction and Mental Health, 60 White Squirrel Way , Toronto, Ontario M6J 1H4, Canada

Abstract

Long-term potentiation (LTP)-like activity can be induced by stimulation protocols such as paired associative stimulation (PAS). We aimed to determine whether PAS-induced LTP-like activity (PAS-LTP) of the dorsolateral prefrontal cortex (DLPFC) is associated with cortical thickness and other structural measures impaired in Alzheimer’s dementia (AD). We also explored longitudinal relationships between these brain structures and PAS-LTP response after a repetitive PAS (rPAS) intervention. Mediation and regression analyses were conducted using data from randomized controlled trials with AD and healthy control participants. PAS-electroencephalography assessed DLPFC PAS-LTP. DLPFC thickness and surface area were acquired from T1-weighted magnetic resonance imaging. Fractional anisotropy and mean diffusivity (MD) of the superior longitudinal fasciculus (SLF)—a tract important to induce PAS-LTP—were measured with diffusion-weighted imaging. AD participants exhibited reduced DLPFC thickness and increased SLF MD. There was also some evidence that reduction in DLPFC thickness mediates DLPFC PAS-LTP impairment. Longitudinal analyses showed preliminary evidence that SLF MD, and to a lesser extent DLPFC thickness, is associated with DLPFC PAS-LTP response to active rPAS. This study expands our understanding of the relationships between brain structural changes and neuroplasticity. It provides promising evidence for a structural predictor to improving neuroplasticity in AD with neurostimulation. This article is part of a discussion meeting issue ‘Long-term potentiation: 50 years on’.

Funder

Brain and Behavior Research Foundation

Weston Brain Institute

Publisher

The Royal Society

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Long-term potentiation: 50 years on: past, present and future;Philosophical Transactions of the Royal Society B: Biological Sciences;2024-06-10

2. Effect of dorsolateral prefrontal cortex structural measures on neuroplasticity and response to paired-associative stimulation in Alzheimer’s dementia;Philosophical Transactions of the Royal Society B: Biological Sciences;2024-06-10

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