Volatile organic compounds and the potential for a lung cancer breath test

Author:

Barash Orna1,Tisch Ulrike1,Haick Hossam2

Affiliation:

1. The Department of Chemical Engineering & Russell Berrie Nanotechnology Institute, Technion – Israel Institute of Technology, Haifa 3200003, Israel

2. The Department of Chemical Engineering & Russell Berrie Nanotechnology Institute, Technion – Israel Institute of Technology, Haifa 3200003, Israel.

Abstract

SUMMARY Detecting exhaled volatile organic compounds (VOCs) that are associated with lung cancer (LC) has realistic potential for becoming an integral part of population-based LC screening and monitoring in the near future. Here, we review the main three approaches for profiling VOCs in LC patients and their advantages and pitfalls: first, mass spectrometry techniques for the identification and/or quantification of a wide variety of separate breath VOCs; second, canines that are trained to sniff out LC; and third, cross-reactive chemical sensors in combination with statistical methods for identifying disease-specific patterns. We estimate that the latter would be most suitable for clinical practice. In the short run, breath testing could provide a critically needed adjunct method for detecting nodule malignancy with high specificity during low-dose computed tomography screening. In the long run, breath testing holds potential for entirely revolutionizing LC screening, diagnosis and management.

Publisher

Future Medicine Ltd

Subject

Pulmonary and Respiratory Medicine,Oncology

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