Abstract
Curcumin, the primary curcuminoid component of turmeric (Curcuma longa L), has been shown to have powerful antibacterial properties, inhibiting the growth of a wide range of infections. The research presented here focuses on current Curcumin nanosystems investigations to aid in the progress of curcumin and its derivatives as comprehensive antiviral therapies. The breakdown rates of curcumin were determined using spectrophotometry, which allowed the compound's stability to be determined using chitosan and Tergitol-15-S-7. Tergentole 5 was also utilised as a surfactant. Hydrophobic contacts, hydrogen bond formation, and electrostatic interactions are examples of exothermic interactions between curcumin and chitosan. Tergitol-15-S-7 impacts the interaction between curcumin and chitosan in large doses, according to an examination of absorption and fluorescence patterns at a physiological pH (7.4). The apparent binding constants and distribution of curcumin within the interior of chitosan have been demonstrated using the fluorescence quenching method. Fluorescence quenching techniques revealed that curcumin distribution in colloidal chitosan solution is not uniform. The hydrophobic interior of chitosan is mostly constrained to its cationic centres, which contain curcumin. Nano curcumin supplementation decreased inflammation, respiratory function, clinical symptoms, and sequelae in people with COVID 19 and other viral infections.