Author:
Nirmalkar Khemlal,Murugesan Selvasankar,Pizano-Zárate María,Villalobos-Flores Loan,García-González Cristina,Morales-Hernández Rosa,Nuñez-Hernández Jorge,Hernández-Quiroz Fernando,Romero-Figueroa María,Hernández-Guerrero César,Hoyo-Vadillo Carlos,García-Mena Jaime
Abstract
Obesity is a metabolic disease characterized by low-grade inflammation and accompanied by dyslipidemia and up-regulation of other bioactive molecules, creating a predisposition to endothelial dysfunction and metabolic syndrome. We studied the association between gut microbiota diversity and endothelial dysfunction (EDF) markers in obese Mexican children and adolescents. We examined clinical data including metabolic factors and EDF markers in blood samples. Gut bacterial diversity was characterized by high-throughput sequencing of V3-16S rDNA libraries. Triglycerides, insulin, homeostasis model assessment-insulin resistant (HOMA-IR), leptin, C-reactive protein (CRP), and EDF marker intercellular adhesion molecule 1 (ICAM-1) were significantly higher in obese children and adolescents. Multivariate analysis showed statistically significant positive associations between vascular cell adhesion molecule 1 (VCAM-1) and Veillonellaceae, and between ICAM-1 and Ruminococcus in obese children. In obese adolescents, there was a statistically significant positive association between total cholesterol and Ruminococcus, and between ICAM-1 and Bacteroides. LEfSe analysis showed that the genus Lactobacillus and family Coriobacteriaceae were enriched in children, and genera Collinsella and Prevotella were enriched in obese adolescents. Obese children and adolescents had higher levels of insulin resistance and metabolic syndrome. These results suggest that obese Mexican children and adolescents had increased levels of CRP and a reduction of adiponectin, which causes higher expression of EDF markers, affecting endothelial function and associating with changes in the gut microbiota.
Funder
Consejo Nacional de Ciencia y Tecnología
Instituto Nacional de Perinatología
Subject
Food Science,Nutrition and Dietetics
Reference58 articles.
1. Obesity and Overweighthttp://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
2. Obesity Update 2017https://www.oecd.org/els/health-systems/Obesity-Update-2017.pdf
3. Directorio Secretaría De Saludhttps://www.gob.mx/cms/uploads/attachment/file/209093/ENSANUT.pdf
4. Human gut microbes associated with obesity
5. Study of the diversity and short-chain fatty acids production by the bacterial community in overweight and obese Mexican children
Cited by
80 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献