Role of Surgery in Metastatic Melanoma and Review of Melanoma Molecular Characteristics-Reference-Cited by-同舟云学术

Role of Surgery in Metastatic Melanoma and Review of Melanoma Molecular Characteristics

Published:2024-03-07 Issue:6 Volume:13 Page:465
ISSN:2073-4409
Container-title:Cells
language:en
Short-container-title:Cells

Author:

Sukniam Kulkaew¹,Manaise Harsheen K.²,Popp Kyle³,Popp Reed⁴,Gabriel Emmanuel⁵^ORCID

Affiliation:

1. Department of General Surgery, Duke University Medical Center, Durham, NC 27707, USA

2. Department of Medicine, Government Medical College and Hospital, Chandigarh 160047, India

3. Department of Medicine, Florida State University, Tallahassee, FL 32306, USA

4. College of Medicine, University of Florida, Gainesville, FL 32611, USA

5. Department of General Surgery, Division of Surgical Oncology, Mayo Clinic Florida, Jacksonville, FL 32224, USA

Abstract

We aimed to review the molecular characteristics of metastatic melanoma and the role of surgery in metastasectomy for metastatic melanoma. We performed a systematic literature search on PubMed to identify relevant studies focusing on several mutations, including NRAS, BRAF, NF1, MITF, PTEN, TP53, CDKN2A, TERT, TMB, EGFR, and c-KIT. This was performed in the context of metastatic melanoma and the role of metastasectomy in the metastatic melanoma population. A comprehensive review of these molecular characteristics is presented with a focus on their prognosis and role in surgical metastasectomy.

Publisher

MDPI AG

Link

https://www.mdpi.com/2073-4409/13/6/465/pdf

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